RootPath @RootPathGx

RootPath is a pioneer in NextGen gene synthesis and SynBio solutions. With clonal, kb-long genes starting from $0.03/bp, we enable biology at scale. rootpath.com Framingham, MA Joined September 2021

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RootPath @RootPathGx

6 months ago

@KevinKaichuang Just to throwing our hat in the ring 😉Happy to help!

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Meet the winners! Based on expert review and social media impact, the five winners of the 1st cycle of Megabase Spark to receive 100 kb of rBlocks™ synthetic DNA are: 🏆 @mcrae_ewan (Houston Methodist) 🏆 Scott Pownall (Open Science Network Society) 🏆 @theicechol (Institute for Medical Engineering and Science, MIT) 🏆 @HansGerstmans (VIB - KU Leuven) 🏆 Hanne Vande Capelle (VIB - KU Leuven) We are inspired by the creativity and ambition of all applicants. Thank you all for submitting your awesome ideas! A huge thank you also goes to our reviewers @ProfTomEllis, @ATinyGreenCell, @timlu and @lecong for lending their expertise and time to evaluate submissions with such rigor. Stay tuned -- cycle 2 of Megabase Spark will open soon!

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RootPath @RootPathGx

11 months ago

We are excited to share another #MegabaseSpark submission, titled 'Bio-Based Petrochemicals' from @sean_wirt: "We plan to survey enzymes for activity on non-native substrates, enabling the construction of novel metabolic pathways for bio-based commodity chemicals traditionally derived from petroleum. This research supports the transition to a robust bioeconomy." Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

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RootPath @RootPathGx

11 months ago

We are excited to share another #MegabaseSpark submission, from @ChrisBatianis: "We wire cell growth to enzyme function: if the enzyme fires, the cell thrives. Thousands of variants turn growth into activity data that train LLM models to design better proteins. Synthesised AI-guided hits push sustainable manufacturing forward." Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

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RootPath @RootPathGx

11 months ago

We are excited to share another #MegabaseSpark submission, from @nehastar03: "We bioengineer microbial biosynthetic gene clusters (BGCs) to unlock cryptic pathways and discover novel antimicrobial compounds. Using heterologous expression and rational design, we aim to produce potent and structurally diverse bioactive metabolites." Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

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RootPath @RootPathGx

11 months ago

We are excited to share another #MegabaseSpark submission, from @AmodRBhat: "Tick-borne flaviviruses are stealthy, neglected threats endemic to me but ignored globally. Tired of watching research stall behind biosafety barriers, I intend to engineer "MiniFlaviReps" that are replication competent VLPs but don't require hazmat suits to conduct research.😁" Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

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RootPath @RootPathGx

11 months ago

With the deadline approaching, we are excited to share another #MegabaseSpark submission, from @HansGerstmans: "Synthetic refactoring and optimization of a biosynthetic gene cluster encoding a potent anti-breast cancer natural product, to improve potency and production in a breast microbiome-resident bacterium." Like and repost if you like this idea! #SynBio #SyntheticBiology #DNA @KU_Leuven @VIB_microbes

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RootPath @RootPathGx

a year ago

Happy Friday! We got a new #MegabaseSpark submission from @lly_sam1: This research uses synthetic biology to determine if all 20 canonical amino acids are essential for life. By designing and testing proteins with fewer amino acids in bacteria, we aim to uncover fundamental life principles and advance protein design and synthetic biology. #SynBio #SyntheticBiology #DNA Like and repost if you like this idea!

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RootPath @RootPathGx

a year ago

@nootlabs_ Information wants to be free!

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RootPath @RootPathGx

a year ago

@simone_minnie @AriaxBio @aaronmring What a great time to be alive!

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RootPath @RootPathGx

a year ago

@mcrae_ewan Want to mint it into an NFT? I know a guy....🤭

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RootPath @RootPathGx

a year ago

We welcome the first ever #MegabaseSpark submission, from @mcrae_ewan: "We’re building a synthetic library of RNA sequence variants to map how mutations reshape RNA folding and function. By encoding thousands of designed variants in synthetic DNA, we aim to uncover design rules for RNA-based therapeutics and nanostructures." Like and repost if you like this idea! #SynBio #RootPath

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RootPath @RootPathGx

a year ago

@AllThingsApx "Enzyme engineering needs kinetics, not just structure." -- As someone who derives k_{cat} and K_M from elemental rate constants in grad school and many years after that for a living, this sentence warms my heart 😃

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RootPath @RootPathGx

a year ago

@aaronmring @AriaxBio Congratulations Aaron! Designed proteins are eating natural proteins 👀

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RootPath @RootPathGx

a year ago

4/ 🗓️ First deadline: June 30 🧬 Apply with a brief project summary, a catchy title, and DNA requirements 🌍 Open to academic, nonprofit researchers as well as entrepreneurs worldwide Apply and learn more here → bit.ly/4d4qCdq

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RootPath @RootPathGx

a year ago

3/ Every quarter, we’ll select proposals from researchers with promising ideas and limited resources that generate popular support (Fan Favorites) or demonstrate exceptional scientific merit (Professional Picks). Winners receive free rBlocks™ DNA — RootPath’s high-quality, sequence-verified dsDNA fragments, up to 3.5 kb in length.

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RootPath @RootPathGx

a year ago

1/ 🚨 Today we’re launching something big: Megabase Spark — RootPath’s new initiative to support bold, underfunded research with free synthetic DNA. We’re giving away 3 million base pairs through 2026. Details 👇 #MegabaseSpark

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RootPath @RootPathGx

a year ago

@johncumbers Looking forward to the session! Can’t wait to share how single cell transcriptome and TCR sequencing inspired our journey in NextGen gene synthesis. See you all in San Jose!