ShorterLab @ShorterLab
Countering deleterious phase transitions in ALS/FTD, PD, AD, and related disorders @Penn @PennMedicine @bb_upenn @BMBGGUPENN @PGGUPenn @PennNGG @CAMBUpenn med.upenn.edu/shorterlab/ind… University of Pennsylvania Joined January 2012-
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ShorterLab retweeted
Cristopher Sánchez becomes just the 5th pitcher since 1893 to record a single-season scoreless innings streak of 50+ IP in a winning effort for the @Phillies!
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ShorterLab retweeted
The early access version of @SanjayaVirajBa1’s study on synthetic mitochondrial condensates is available now in @CommsBio! This marks the first publication from the lab!
Membranes arrest the coarsening of mitochondrial condensates in human cells: Communications Biology, Published online: 23 April 2026; doi:10.1038/s42003-026-10085-3Optogenetically controlled phase separation in live mitochondria reveals how membranes… dlvr.it/TSnkW3
ShorterLab retweeted
5 years ago, I asked Doug Wallace, "What happens if we infect cells lacking mito DNA with SARS-CoV-2? Can the virus make more virus (replicate)?" We're floored by the answer & excited to share our team effort across @ChildrensPhila & @neidl @BU_Tweets with you!
Mitochondrial OXPHOS restricts SARS-CoV-2 replication | Science Advances, exciting work by @YentliSA et al. science.org/doi/10.1126/sc…
Mitochondrial OXPHOS restricts SARS-CoV-2 replication | Science Advances, exciting work by @YentliSA et al. science.org/doi/10.1126/sc…
A cytoplasmic turn in TDP-43 toxicity: Neuron cell.com/neuron/fulltex…
Multimodal control of Cas13d activity through domain insertion at an allosteric hotspot: nature.com/articles/s4146…
Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction | Science Translational Medicine science.org/eprint/MAJFTSR…
Conserved RNA helicase Vasa regulates ribonucleoprotein condensate dynamics and mRNA localization: iScience cell.com/iscience/fullt…
Short RNAs may prevent neuron death linked to ALS, dementia: nih.gov/news-events/ni…
Coordinated expression and assembly of BiP, p58IPK, and ER chaperone complexes maximize proinsulin folding in pancreatic β cells | PNAS pnas.org/doi/10.1073/pn…
miR-146a is a pleiotropic regulator of motor neuron degeneration | PNAS pnas.org/doi/10.1073/pn…
Srrm2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a genetic mouse model of schizophrenia: Cell Reports cell.com/cell-reports/f…
RNA-binding protein diversity and NLS arginines regulate FUS mixing in mRNA-rich compartments: Cell Reports cell.com/cell-reports/f…
Kinase condensates enrich ATP and trigger autophosphorylation: Cell Reports cell.com/cell-reports/f…
Mapping interactions between disordered regions reveals promiscuity in biomolecular condensate formation: nature.com/articles/s4146…
Intracellular neuronal recordings across DNA tiles: nature.com/articles/s4156…
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