Turvey lab @TurveyLab
Dr. Stuart Turvey and the Turvey lab are commited to improving child health through research. Our research transforms lives. There is urgency to what we do! turveylab.com UBC and BCCH, Vancouver,Canada Joined February 2017-
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Thanks for promoting our discovery @FranMartinezGr
Human germline biallelic loss-of-function OSMR variants cause severe allergic disease #RareDisease #Genetics #morbidgene rupress.org/jhi/article/2/…
So great to partner with @SateeshMad93871 on this new discovery!
Excited to share our new collaborative paper establishing biallelic OSMR deficiency as a novel primary atopic disorder! Human germline biallelic loss-of-function OSMR variants cause severe allergic disease rupress.org/jhi/article/2/…
Excited to share our new collaborative paper establishing biallelic OSMR deficiency as a novel primary atopic disorder! Human germline biallelic loss-of-function OSMR variants cause severe allergic disease rupress.org/jhi/article/2/…
هكذا يتراكم العلم؛ ملاحظة تقود لاكتشاف، واكتشاف يفتح بابا لفهم أعمق. قبل سنة تقريبًا، وصفنا جين ال OSM كسبب جديد لفشل نخاع العظم، واليوم دراسة جديدة توضح أن نقص المستقبل المرتبط فيه OSMR deficiency يسبب أمراض حساسية شديدة ومبكرة. المثير للاهتمام أن الدراسة تلمّح لفكرة مهمة,غياب الجين نفسه يؤثر على تكوّن ووظيفة نخاع العظم، بينما غياب المستقبل يعطّل إشارات مناعية والتهابية مرتبطة بالجلد والحساسية. هذا مثال جميل على كيف أن نفس المسار الحيوي ممكن يرتبط بأمراض مختلفة تمامًا حسب موقع الخلل فيه.
تم التعرف على جين جديد يُسمى OSM مرتبط بحالات فشل نخاع العظم الوراثي، وذلك من خلال عمل بحثي شاركت فيه مع فريق علمي، ونُشر في مجلة The Journal of Clinical Investigation هذا العمل بدأ كحالة تحليل سلبي للاكزوم ، لكن من خلال إعادة قراءة التحليل الدقيقة، تمكنا من اكتشاف طفرة تؤدي
A new human inborn error of immunity: OSMR deficiency can underlie the HIES Oncostatin M receptor deficiency as a novel candidate genetic cause of autosomal recessive hyper-IgE syndrome rupress.org/jhi/article/2/…
A surprising and exciting observation ! Human germline biallelic loss-of-function OSMR variants cause severe allergic disease rupress.org/jhi/article/2/…
👍👍I agree @Info4PI! For patients with inborn errors of immunity, genetic counseling helps families make sense of a genetic diagnosis while also advancing the knowledge that leads to better diagnoses, treatments, and outcomes for future patients.
🧬 Genetic counseling is a process that helps individuals and families understand the likelihood of a genetic condition and what that risk may mean for them. For families affected by #PrimaryImmunodeficiency, genetic counseling can provide clarity, guide decisions about genetic
New human inborn error of immunity! By identifying biallelic OSMR deficiency as a novel Primary Atopic Disorder, we uncover a previously unrecognized mechanism driving severe allergic disease and provide new insights into the biology of human atopy.
New human primary atopic disorder defined: @SimranKaurSamra and Sharma et al. @TurveyLab @UBC show OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. hubs.la/Q04jcnX50 #Immunology #Genetics #Atopy #IEIs
New human primary atopic disorder defined: @SimranKaurSamra and Sharma et al. @TurveyLab @UBC show OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. hubs.la/Q04jcnX50 #Immunology #Genetics #Atopy #IEIs
Check out our new Editorial comment: Italian pediatric experts consensus statement on diagnosis and management of primary atopic disorders' - Vaseghi‐Shanjani - 2026 - Pediatric Allergy and Immunology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/pa…
Instead of studying asthma only after children get sick, Dr. Stuart Turvey and his team at @UBC have taken a different approach. 💩 By analyzing infant stool samples, researchers found differences in gut bacteria that were associated with later development of #asthma: bit.ly/4rqPbHa
Monogenic disorders of the IRF transcription factors. Review by Mattison Stojcic, Pariya Yousefi, Catherine Biggs, and Stuart Turvey: hubs.la/Q046V_810 📘 In our #InnateImmunity collection: hubs.la/Q046VVBm0 #KSInnateImmune26
New CHILD research in @CellReports by Darlene Dai, Charisse Petersen, @TurveyLab et al. suggests #breastfeeding 🤱may reduce socioeconomic-based differences in children’s chronic disease risk by influencing the infant gut #microbiome 💩@BCCHresearch More: childcohort.ca/ses-breastfeed…
New review: Allergy can be a genetic disease. Modi et al. show how primary atopic disorders reveal mechanisms controlling barrier integrity, immune signaling and tolerance, and inform precision therapies. From @TurveyLab: hubs.la/Q04fQSwn0 #Atopy #Therapeutics
Who would have thought 30 yrs ago that there would be > 50 inborn errors of immunity underlying atopy ? This has been the most insightful study of allergy: Primary atopic disorders: Monogenic insights into immunity rupress.org/jhi/article/2/…
The Current with Matt Galloway - March 9, 2026: How a gene edit gave a B.C teen his life back cbc.ca/listen/live-ra…
Stuart Turvey and colleagues @BCChildrensHosp review how the early life #microbiome shapes immune programming in childhood #asthma and #allergies: mucosalimmunology.org/article/S1933-…
What can dirty diapers tell us about #asthma? Clues from the gut #microbiome are reshaping how we understand pediatric asthma and allergies! Breastfeeding, B. infantis, and early microbial exposures matter. @WashUMedPeds #Keynote by Stuart Turvey
ASXL1 deficiency causes epigenetic dysfunction, combined #immunodeficiency, and EBV-associated lymphoma, say Maggie Fu, Mehul Sharma, Michael Kobor, Stuart Turvey, Catherine Biggs et al. hubs.la/Q03zN1k20 #InbornErrorsOfImmunity
Ultimate precision medicine! Delighted to have played a small part to ensure our patient from @BCChildrensHosp was able to receive this remarkable curative treatment. Kudos to @ElieHaddad55 for launching this trial in Canada. @NEJM @UBCNews @BCCHF @GenomeBC @GenomeCanada
B.C. teen becomes first in the world cured of rare disease using gene editing 18-year-old Ty Sperle from UBC Okanagan was Participant 1 in the trial. He had chronic granulomatous disease since age 5 and is now completely cured after the gene edit fixed his immune cells.
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